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Research news

Updates on our research grants and lots of fantastic publications from our talented staff.


Research update.
Research update.

Research grants submitted

Professor Arunasalam Dharmarajan submitted four NHMRC grant applications.  He is CIA, CIB, CIC and CIF on each of the submitted grants.

The school was able to submit many other grants to the NHMRC, ARC or Raine foundation (priming grants) in March 2017, where staff acted in the capacity of CIA or at other investigator levels.

Recent publications from school staff

The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins.

Bharadwaj P, Wijesekara N, Liyanapathirana M, Newsholme P, Ittner L, Fraser P, Verdile G.

J Alzheimers Dis. 2017 Mar 1. doi: 10.3233/JAD-161192. [Epub ahead of print]

PMID:28269785

Specific ranges of anti-Mullerian hormone and antral follicle count correlate to provide a prognostic indicator for IVF outcome.

Keane K, Cruzat VF, Wagle S, Chaudhary N, Newsholme P, Yovich J.

Reprod Biol. 2017 Mar;17(1):51-59. doi: 10.1016/j.repbio.2016.12.002. Epub 2017 Jan 26.

PMID:28132758

Interactions of phosphate solubilising microorganisms with natural rare-earth phosphate minerals: a study utilizing Western Australian monazite.

Corbett MK, Eksteen JJ, Niu XZ, Croue JP, Watkin EL.

Bioprocess Biosyst Eng. 2017 Mar 21. doi: 10.1007/s00449-017-1757-3. [Epub ahead of print]

PMID: 28324179

Draft Genome Sequence of the Acidophilic, Halotolerant, and Iron/Sulfur-Oxidizing Acidihalobacter prosperus DSM 14174 (Strain V6).

Khaleque HN, Ramsay JP, Murphy RJ, Kaksonen AH, Boxall NJ, Watkin EL.

Genome Announc. 2017 Jan 19;5(3). pii: e01469-16. doi: 10.1128/genomeA.01469-16.

PMID:28104654

Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing Cognitive Decline.

Shah TM, Weinborn M, Verdile G, Sohrabi HR, Martins RN.

Neuropsychol Rev. 2017 Mar;27(1):62-80. doi: 10.1007/s11065-016-9338-9. Epub 2017 Jan 14. Review.

PMID:28092015

Molecular Dynamics Simulation of Tau Peptides for the Investigation of Conformational Changes Induced by Specific Phosphorylation Patterns.

Gandhi NS, Kukic P, Lippens G, Mancera RL.

Methods Mol Biol. 2017;1523:33-59.

PMID:27975243

The genetic architecture of the MHC class II region in British Texel sheep.

Ali AO, Stear A, Fairlie-Clarke K, Brujeni GN, Isa NM, Salisi MS, Donskow-Łysoniewska K, Groth D, Buitkamp J, Stear MJ.

Immunogenetics. 2017 Mar;69(3):157-163. doi: 10.1007/s00251-016-0962-6. Epub 2016 Dec 5.

PMID:27921144

The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa.

Shanahan R, Reen FJ, Cano R, O’Gara F, McGlacken GP.

Org Biomol Chem. 2017 Jan 4;15(2):306-310. doi: 10.1039/c6ob01930g.

PMID:27901165

Class II Phosphoinositide 3-Kinases as Novel Drug Targets.

Falasca M, Hamilton JR, Selvadurai M, Sundaram K, Adamska A, Thompson PE.

J Med Chem. 2017 Jan 12;60(1):47-65. doi: 10.1021/acs.jmedchem.6b00963. Epub 2016 Oct 21.

PMID:27644332

Grzelak CA, Sigglekow ND, Tirnitz-Parker JE, Hamson EJ, Warren A, Maneck B, Chen J, Patkunanathan B, Boland J, Cheng R, Shackel NA, Seth D, Bowen DG, Martelotto LG, Watkins DN, McCaughan GW. (2017) Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease. PLoS One. Feb 10;12(2):e0171480. doi: 10.1371/journal.pone.0171480.

Ali, K.A., Hassan, M.E. & Elnashar, M.M.M. (2017) Development of functionalized carrageenan, chitosan and alginate as polymeric chelating ligands for water softening. Int. J. Environ. Sci. Technol. doi:10.1007/s13762-017-1298-y

Dai X, Wang L, Deivasigamni A, Looi CY, Karthikeyan C, Trivedi P, Chinnathambi A, Alharbi SA, Arfuso F, Dharmarajan A, Goh BC, Hui KM, Kumar AP, Mustafa MR, Sethi G. (2017) A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma. Oncotarget. 8:12831-12842. doi: 10.18632/oncotarget.14606

Swamy SG, Kameshwar VH, Shubha PB, Looi CY, Shanmugam MK, Arfuso F, Dharmarajan A, Sethi G, Shivananju NS, Bishayee A. (2017) Targeting multiple oncogenic pathways for the treatment of hepatocellular carcinoma. Target Oncol. Feb;12(1):1-10. doi: 10.1007/s11523-016-0452-7.

Bhuvanalakshmi G., Basappa , Rangappa Kanchugarakoppal S., Dharmarajan Arun, Sethi Gautam, Kumar Alan P., Warrier Sudha. (2017) Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4. Frontiers in Pharmacology, 8:124. doi 10.3389/fphar.2017.00124

Articles in press

Saran U, Priya MK, Balaguru UM, Swaminathan A, Nagarajan S, Dharmarajan A, Chatterjee S. (In press) sFRP4 signalling of apoptosis and angiostasis uses nitric oxide-cGMP-permeability axis of endothelium. Nitric Oxide. 2017 Mar 3. pii: S1089-8603(16)30092-1. doi: 10.1016/j.niox.2017.02.012.

Regan SL, Knight PG, Yovich JL, Stanger JD, Leung Y, Arfuso F, Dharmarajan A, Almahbobi G. (In press) Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles. Mol Cell Endocrinol. 2017 Feb 7. pii: S0303-7207(17)30087-4. doi: 10.1016/j.mce.2017.02.007.

Perumal V, Dharmarajan A, and Fox S (2017). The Wnt regulator SFRP4 inhibits mesothelioma cell proliferation, migration, and antagonizes Wnt3a via its netrin-like domain. International Journal of Oncology (accepted for publication).

Pohl, S, Brook, N, Agostino, M, Arfuso, F, Dharmarajan A (2017). Wnt signaling in triple-negative breast cancer. Oncogenesis (accepted for publication)

Abhijeet Deshmukh, Frank Arfuso, Philip Newsholme, Arun Dharmarajan (2017).Secreted Frizzled-related protein 4 (sFRP4) chemo-sensitizes cancer stem cells derived from human breast, prostate, and ovary tumor cell lines. Scientific Reports (accepted for publication).