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Research publications

Recent Publications from Biomedical Sciences 

Click here for a full list of 2015 publications

Calton EK, Keane KN, Newsholme P and Soares MJ (2015) The impact of Vitamin D levels on inflammatory status: a systematic review of immune cell studies. PLoS ONE 10(11): e0141770. doi:10.1371/journal.pone.0141770

Carnagarin R, Dharmarajan AM, and Dass CR (2015). PEDF attenuates insulin-dependent molecular pathways of glucose homeostasis in skeletal myocytes.  Molecular and Cellular Endocrinology (in press).

Chen Y, Cruzat VF and Newsholme P (2016) Beta cell metabolism, Insulin Production and Secretion: Metabolic failure resulting in Diabetes. In: Molecular Nutrition and Diabetes. Didac Mauricio (ed.) pp29-40 ISBN: 978-0-12-801585-8 Academic Press / Elsevier London, Oxford, San Diego

Cruzat VF, Keane KN, Scheinpflug AL, Cordeiro R, Soares M and Newsholme P (2015) Alanyl-Glutamine improves pancreatic β-cell function following ex vivo inflammatory challenge. J Endocrinol. 224: 261-271 DOI: 10.1530/JOE-14-0677

Firns S, Cruzat VF, Keane KN, Joesbury KA, Lee AH, Newsholme P, Yovich JL. (2015) The effect of cigarette smoking, alchol consumption and fruit and vegetable consumption on IVF outcomes: a review and presentation of original data. Reprod Biol Endocrinol. 13:134. doi: 10.1186/s12958-015-0133-x.

Keane KN, Hinchliffe PM, Namdar N, Conceicao JL, Newsholme, P and Yovich JL (2015)Novel dehydroepiandrosterone troche supplementation improves the serum androgen profile of women undergoing in vitro fertilization. Drug Design, Development and Therapy. 2015:9 1-10

Keane KN, Calton EK, Cruzat VF, Soares MJ and Newsholme P (2015) The Impact of Cryopreservation on human peripheral blood leukocyte bioenergetics. Clin Sci (Lond) 2015 Jan 19

Keane KN, Cruzat VF, Carlessi R, Homem de Bittencourt Jr PI and Newsholme P (2015) Molecular events linking Oxidative Stress and Inflammation to Insulin Resistance and beta-cell dysfunction. Oxidative Medicine and Cellular Longevity. Volume 2015, Article ID 181643, 15 pages

Krause M, Bock PM, Takahashi HK, Homem de Bittencourt Jr. PI, and Newsholme P (2015) The regulatory roles of NADPH oxidase, intra and extracellular HSP70 in pancreatic islet function, dysfunction and diabetes. Clin Sci (Lond) 128(11):789-803 doi: 10.1042/CS20140695.

McEvoy, B, Sumayao R, Slattery C, McMorrow T and Newsholme P (2015) Cystine accumulation attenuates insulin release from the pancreatic beta cell due to elevated oxidative stress and decreased ATP levels. J. Physiol. 593(23):5167-82. doi: 10.1113/JP271237

Perumal V, Pohl, S, Keane, KN, Arfuso, F, Newsholme, P, Fox, S, Dharmarajan A (2016).  Therapeutic approach to target mesothelioma cancer cells using the Wnt antagonist, secreted frizzled-related protein 4: Metabolic state of cancer cells.  Experimental Cell Research (in press)

Regan SLP, Knight PG, Yovich J, Stranger J, Leung Y, Arfuso F,  Dharmarajan A, Almahbobi G (2015). Dysregulation of granulosal bone morphogenetic protein receptor 1B density is associated with reduced ovarian reserve and the age-related decline in human fertility.   Molecular and Cellular Endocronology (in press).

Selvi RB,  Swaminathan A,  Chatterjee S, Shanmugam MK,  Li F, Ramakrishnan GB,  Siveen KS,  Chinnathambi A,  Emam ZM,  Alharbi SA,  Basha J, Bhat A, Vasudevan M,  Dharmarajan A, Sethi G, and Kundu TK (2015).  Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model. Oncotarget. 6, 43806-4318. (accepted on October 27)

Singh,SS, Yap WN,  Arfuso F, Kar S, Wang C, Wanpei C, Dharmarajan AM,  Sethi G, Kumar AP (2015). Targeting the PI3K/Akt Signaling Pathway in Gastric Carcinoma: A reality for personalized medicine?  World Journal of Gastroenterology (In Press).  Review

Sidarala V, Veluthakal R, Syeda K, Vlaar C, Newsholme P and Kowluru A (2015) Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic b-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1). Biochem Pharmacol 95(4):301-10. doi: 10.1016/j.bcp.2015.04.001

Verdile G, Keane KN, Cruzat VF Medic S, Sabale M, Rowles J, Wijesekara N, Martins RN, Fraser PE and Newsholme P (2015) Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer’s disease. Mediators of Inflammation 2015:105828. doi: 10.1155/2015/105828. Epub 2015 Nov 26.

Visweswaran M, Pohl S, Arfuso F, Newsholme P, Dilley R, Pervaiz S and Dharmarajan A (2015) Multi-lineage differentiation of mesenchymal stem cells – Wnt or not to Wnt. The international Journal of Biochemistry and Cell Biology. 68:139-47. doi: 10.1016/j.biocel.2015.09.008

Visweswaran M, Schiefer L, Arfuso, F, Dilley R, Newsholme P and Dharmarajan A (2015) Wnt antagonist secreted frizzled-related protein 4 upregulates adipogenic differentiation in human adipose tissue-derived mesenchymal stem cells. PLoS ONE 10 (2):e0118005. doi: 10.1371/journal.pone.0118005. eCollection 2015