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Recent publications

Regulatory principles in metabolism-then and now.

Curi R, Newsholme P, Marzuca-Nassr GN, Takahashi HK, Hirabara SM, Cruzat V, Krause M, de Bittencourt PI Jr.

Biochem J. 2016 Jul 1;473(13):1845-57. doi: 10.1042/BCJ20160103. Review.


Pigment epithelium-derived factor stimulates skeletal muscle glycolytic activity through NADPH oxidase-dependent reactive oxygen species production.

Carnagarin R, Carlessi R, Newsholme P, Dharmarajan AM, Dass CR.

Int J Biochem Cell Biol. 2016 Jun 22;78:229-236. doi: 10.1016/j.biocel.2016.06.013. [Epub ahead of print]


Determination of the anti-inflammatory and cytoprotective effects of l-glutamine and l-alanine, or dipeptide, supplementation in rats submitted to resistance exercise.

Raizel R, Leite JS, Hypólito TM, Coqueiro AY, Newsholme P, Cruzat VF, Tirapegui J.

Br J Nutr. 2016 Aug;116(3):470-9. doi: 10.1017/S0007114516001999. Epub 2016 May 24.


Gut associated bacteria are critical to metabolism, inflammation and health.

Newsholme P, Homem de Bittencourt PI Jr.

Curr Opin Clin Nutr Metab Care. 2016 Jul;19(4):245-9. doi: 10.1097/MCO.0000000000000293. No abstract available.


Housekeeping proteins: How useful are they in skeletal muscle diabetes studies and muscle hypertrophy models?

Fortes MA, Marzuca-Nassr GN, Vitzel KF, da Justa Pinheiro CH, Newsholme P, Curi R.

Anal Biochem. 2016 Jul 1;504:38-40. doi: 10.1016/j.ab.2016.03.023. Epub 2016 Apr 6.


Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis.

Yuan Y, Cruzat VF, Newsholme P, Cheng J, Chen Y, Lu Y.

Mech Ageing Dev. 2016 Apr;155:10-21. doi: 10.1016/j.mad.2016.02.003. Epub 2016 Mar 7. Review.


Lysosomal cystine accumulation promotes mitochondrial depolarization and induction of redox-sensitive genes in human kidney proximal tubular cells.

Sumayao R, McEvoy B, Newsholme P, McMorrow T.

J Physiol. 2016 Jun 15;594(12):3353-70. doi: 10.1113/JP271858. Epub 2016 Apr 10.


Pigment epithelium-derived factor (PEDF) regulates metabolism and insulin secretion from a clonal rat pancreatic beta cell line BRIN-BD11 and mouse islets.

Chen Y, Carlessi R, Walz N, Cruzat VF, Keane K, John AN, Jiang FX, Carnagarin R, Dass CR, Newsholme P.

Mol Cell Endocrinol. 2016 May 5;426:50-60. doi: 10.1016/j.mce.2016.02.004. Epub 2016 Feb 8.


Other publications

Dr Josh Ramsay recently published an invited Letter to the Editor in the journal Mobile Genetic Elements (MGE), reviewing work that was published in the Nucleic Acids Research (which won a Faculty of Health Sciences High-Impact-Factor award) and in Journal of Bacteriology.

In the Letter to the Editor, Dr Ramsay, et. al. reviewed and further documented work carried out by the School of Biomedical Sciences lecturer David E. Townsend (who sadly passed away this year) in the 1980s at Curtin, and revealed how important his discoveries were to our present understanding of antibiotic-resistance gene transfer in the bacterial pathogen “Methicillin Resistant Staphylococcus aureus” (MRSA).

Dr Ramsay was also an invited speaker at the recent Australian Society for Microbiology meeting in Perth where he presented the research documented in this Letter.

The Letter to the Editor in MGE was dedicated to David E. Townsend’s memory:


The Authors and the School of Biomedical Sciences, Curtin

University, dedicate this letter to the memory of David E.

Townsend, for his substantial contribution to our understanding

of conjugative plasmids in staphylococcal bacteria. Q.N.

and K.J.P. credit D. Townsend for his supervision of the shot-

gun-cloning and Sanger-sequencing experiments leading to

the sequence of pWBG4.