Research areas at the CHIRI Research Precinct include:
Age associated blood and blood vessel disorders
The Curtin Health Innovation Research Institute boasts significant strengths and is investigating novel approaches for treatment of a range of vascular-based disorders common in older age. We host world-class research in bleeding and clotting disorders; nutrient-gene regulation of blood vessel architecture relevant to peripheral vascular disease, cardiovascular disorders, kidney function and retinal dysfunction. Other novel projects include regulation of blood vessel integrity and function, pivotal to the progression of several major disease conditions including-tumour growth; Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and epilepsy.
Immune function may become compromised with older age. In addition to increased susceptibility to infectious disorders, there is increased prevalence of auto-immune disorders with aging. Accumulating evidence also indicates a complex interplay of immune dysfunction with cancer risk and as a consequence poorer response to cancer therapies with older age. The Curtin Health Innovation Research Institute is privileged to host several extraordinary research groups with fresh approaches to current disease paradigms. Novel insight describing the pathway and potential ‘break points’ of chronic lung infections; key immune-associated regulatory pathways for breast, prostate and bone cancer; and new research investigating immune response phenomena in several neurological disorders.
Alzheimer’s disease and other dementias
Alzheimer’s disease and other dementias: Maintaining memory and cognitive function with older age is of great concern to many older-aged Australians. The Curtin Health Innovation Research Institute has adopted an holistic approach to consider this spectrum of disorder. Integrated research that embodies vascular disturbances and immune dysfunction; research delineating key pathways regulating the pathological evolution of the disorder; coupled with novel state-of-art nutrition and pharmacological-epigentic studies has permitted identification of several potential new pathways for treatment.