The School of Biomedical Sciences Research and Development Committee has initiated a research seminar series that is aimed at highlighting the research that is being undertaken within the School, as well as research undertaken by current and potential Adjuncts to the School.
The HDR seminars give final year students an opportunity to present their research from the previous 3 (or 4) years while the candidacy seminars are aimed at providing the first opportunity to new HDR students to present their proposed research projects to all staff and receive feedback.
The seminars are held approximately fortnightly, followed by refreshments in the building 305 staff room. Location TBA before each seminar.
Gonadotropins, testosterone and Type 2 diabetes: Contributions to risk and pathogenesis of sporadic Alzheimer’s disease
Associate Professor Giuseppe Verdile
Date: Thursday, 17 November
Time: 1-2 pm
A light lunch will be provided from 12.30 pm at the venue
In contrast to Autosomal Dominant Alzheimer’s disease (ADAD) associated with disease causing genetic mutations, development of the more common sporadic AD (sAD) is associated with multiple risk factors. This presentation discusses two such risk factors, age-related changes in sex hormones and gonadotropins and Type 2 Diabetes.
The talk will outline findings from human and animal studies implicating testosterone and luteinizing hormone in cognitive functioning and AD pathogenesis and targeting these hormones as potential therapeutic approaches.
More recent work will also be presented that investigates the impact of type 2 diabetes on cognition and neurodegeneration, and evidence that AD related proteins could contribute to peripheral insulin resistance.
About the speaker
Giuseppe Verdile is Principal Research Fellow and lab head of the Alzheimer’s Disease Research Group, within the School of Biomedical Sciences at Curtin University. He obtained his Ph.D. from the University of Western Australia in 2002. Prior to his current position he was a senior researchers within Professor Ralph Martins group at Edith Cowan University.
His research focus is the molecular understanding of Alzheimer’s disease, where he utilises in vitro and in vivo models to understand mechanisms underlying the neurodegenerative process in the disease. Particular research areas include: understanding structure, function and mechanistic action of the beta amyloid generating enzyme, gamma secretase; regulation of beta amyloid by testosterone and luteinizing hormone and more recently underlying mechanisms linking diabetes and dementia.