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Research news

Research grants awarded

Dr Nina Tirnitz-Parker and Associate Professor Leon Adams, from Sir Charles Gairdner Hospital, were awarded a 2017 Gastroenterological Society of Australia Research Collaboration Award ($30,000) commencing 1 August 2017 and concluding 31 July 2018 for the project titled ‘Liver progenitor cells as a therapeutic target in non-alcoholic fatty liver disease’.

Recent publications

Navdeep Dhami, Walaa Alsubhi, Elizabeth Watkin, Abhijit Mukherjee (2017). Bacterial community dynamics and Biocement formation during stimulation and augmentation: Implications for soil consolidation. Front. Microbiol., 11 July 2017 |

Himel Khaleque, Joshua Ramsay, Riley Murphy, Anna Kaksonen, Naomi Boxall, Elizabeth L. J. Watkin (2017). Draft genome sequence of Acidihalobacter ferrooxidans DSM 14175 (strain V8), a new iron- and sulfur-oxidizing, halotolerant, acidophilic species. Genome Announc. May 2017; 5:Doi:10.1128/Genomea.00413-17

Himel Khaleque, Joshua Ramsay, Riley Murphy, Anna Kaksonen, Naomi Boxall, Elizabeth L. J. Watkin (2017). Draft genome sequence of the acidophilic, halotolerant, and iron/sulfur-oxidizing Acidihalobacter prosperus DSM 14174 (strain V6). Genome Announc. January 2017 5:Doi:10.1128/Genomea.01469-16

Elaine M. Davison, Danielle Giustiniano, Laurton E. Mcgurk, Elizabeth L.J. Watkin, Neale L. Bougher Neotypification and redescription of Amanita preissii (Basidiomycota), and reconsideration of the status of A. griseibrunnea. Nuytsia 28:193-204

MK Corbett, JJ Eksteen, ELJ Watkin (2017). Application of phosphate solubilizing microorganisms on Western Australian monazite ores. Bioprocess and Biosystems Engineering. 40(6), 929-942 doi 10.1007/s00449-017-1757-3

Mark Dopson, David S. Holmes, Marcelo Lazcano, Timothy J. McCredden, Christopher G. Bryan, Kieran T. Mulroney, Robert Steuart, Connie Jackaman and Elizabeth L. J. Watkin (2017). Multiple osmotic stress responses in Acidihalobacter prosperus result in tolerance to chloride ions. Front. Microbiol., 05 January 2017 |

Caparros-Martin, Jose, R. Lareu, Ricky, Ramsay, Joshua & Peplies, Jörg, Jerry Reen, F & A. Headlam, Henrietta, C. Ward, Natalie, D. Croft, Kevin, Newsholme, Philip, D. Hughes, Jeffery & O’Gara, Fergal. (2017). Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism. Microbiome. 5. . 10.1186/s40168-017-0312-4.

Deshmukh, A., Binju, M., Arfuso, F., Newsholme, P., & Dharmarajan, A. (2017). Role of epigenetic modulation in cancer stem cell fate. International Journal of Biochemistry and Cell Biology, 90, 9-16. doi:10.1016/j.biocel.2017.07.003

Deshmukh, A., Kumar, S., Arfuso, F., Newsholme, P., & Dharmarajan, A. (2017). Secreted frizzled-related protein 4 (sFRP4) chemo-sensitizes cancer stem cells derived from human breast, prostate, and ovary tumor cell lines. Scientific Reports, 7(1) doi:10.1038/s41598-017-02256-4

Perumal, V., Dharmarajan, A. M., & Fox, S. A. (2017). The wnt regulator SFRP4 inhibits mesothelioma cell proliferation, migration, and antagonizes Wnt3a via its netrin-like domain. International Journal of Oncology, 51(1), 362-368. doi:10.3892/ijo.2017.4011

Agostino, M., Pohl, S. G., & Dharmarajan, A. (2017). Structure-based prediction of wnt binding affinities for frizzled-type cysteine-rich domains. The Journal of Biological Chemistry, 292(27), 11218-11229. doi:10.1074/jbc.M117.786269

Bhuvanalakshmi, G., Basappa, Rangappa, K. S., Dharmarajan, A., Sethi, G., Kumar, A. P., & Warrier, S. (2017). Breast cancer stem-like cells are inhibited by diosgenin, a steroidal saponin, by the attenuation of the wnt β-catenin signaling via the wnt antagonist secreted frizzled related protein-4. Frontiers in Pharmacology, 8(MAR) doi:10.3389/fphar.2017.00124

Pohl, S. -., Brook, N., Agostino, M., Arfuso, F., Kumar, A. P., & Dharmarajan, A. (2017). Wnt signaling in triple-negative breast cancer. Oncogenesis, 6(4) doi:10.1038/oncsis.2017.14

Saran, U., Mani, K. P., Balaguru, U. M., Swaminathan, A., Nagarajan, S., Dharmarajan, A. M., & Chatterjee, S. (2017). sFRP4 signalling of apoptosis and angiostasis uses nitric oxide-cGMP-permeability axis of endothelium. Nitric Oxide – Biology and Chemistry, 66, 30-42. doi:10.1016/j.niox.2017.02.012

Regan SL, Knight PG, Yovich JL, Stanger JD, Leung Y, Arfuso F, Dharmarajan A, Almahbobi G. (2017). Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles. Molecular and Cellular Endocrinology, 446, 40-51. doi:10.1016/j.mce.2017.02.007

Dai X, Wang L, Deivasigamni A, Looi CY, Karthikeyan C, Trivedi P, Chinnathambi A, Alharbi SA, Arfuso F, Dharmarajan A, Goh BC, Hui KM, Kumar AP, Mustafa MR, Sethi G.. (2017). A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma. Oncotarget, 8(8), 12831-12842. doi:10.18632/oncotarget.14606

Zhongli Shi, Wayne K. Greene, Philip K. Nicholls, Dailun Hu, Janina E. E.Tirnitz-Parker, Qionglan Yuan, Changfu Yin, Bin Ma. Immunofluorescent characterization of non-myelinating Schwann cells and their interactions with immune cells in mouse mesenteric lymph node. European Journal of Histochemistry 2017; 61:2827, 193-203.

McGonigle TA, Dwyer AR, Greenland EL, Scott NM, Keane KNNewsholme P, Goodridge HS, Zon LI, Pixley FJ, Hart PH (2017) PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo. Exp Hematol. 2017 Aug 16. pii: S0301-472X(17)30717-8.

doi: 10.1016/j.exphem.2017.08.002. [Epub ahead of print]

Laws SM, Gaskin S, Woodfield A, Srikanth V, Bruce D, Fraser P, Porter T, Newsholme P, Wijesekara N, Burnham S, Doré V, Li Q-X, Maruff  P, Masters CL, Rainey-Smith S, Rowe CC, Salvado O, Villemagne VL, Martins RN, Verdile G (2017) Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults Sci Rep. 2017 In Press

Caparrós-Martín JA, Lareu RR, Ramsay JP, Peplies J, Jerry Reen F, Headlam HA, Ward NC, Croft KD, Newsholme P, Hughes JD, O’Gara F (2017) Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism. Microbiome. 2017 Aug 9; 5(1):95. doi: 10.1186/s40168-017-0312-4.

McGonigle TA, Keane KN, Ghaly S, Carter KW, Anderson D, Scott NM, Goodridge HS, Dwyer A, Greenland E, Pixley FJ, Newsholme P, Hart PH (2017) UV Irradiation of Skin Enhances Gycolytic Flux and Reduces Migration Capabilities in Bone Marrow-Differentiated Dendritic cells. Am J Pathol. 2017 Jul 11. pii: S0002-9440(17)30388-7. doi: 10.1016/j.ajpath.2017.06.003. [Epub ahead of print]

Carlessi R, Chen Y, Rowlands J, Cruzat VF, Keane KN, Egan L, Mamotte C, Stokes R, Gunton JE, Bittencourt PIH, Newsholme P (2017) GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation. Sci Rep. 2017 Jun 1;7(1):2661. doi: 10.1038/s41598-017-02838-2.

Curi R, de Siqueira Mendes R, de Campos Crispin LA, Norata GD, Sampaio SC, Newsholme P. (2017) A past and present overview of macrophage metabolism and functional outcomes. Clin Sci (Lond). 2017 Jun 15;131(12):1329-1342. doi: 10.1042/CS20170220. Review.

Deshmukh A, Binju M, Arfuso FNewsholme P, Dharmarajan A. (2017) Role of epigenic modulation in cancer stem cell fate. Int J Biochem Cell Biol. 2017 Jul 12;90:9-16. doi: 10.1016/j.biocel.2017.07.003. [Epub ahead of print] Review.

Articles in press

Yi-An Ko, M. Fairuz B. Jamaluddin , Mariam Adebayo, Preety Bajwa, Rodney J. Scott, Arunasalam M. Dharamarajan, Pravin Nahar, Pradeep S. Tanwar (2017). Extracellular Matrix (ECM) Activates -Catenin Signaling in Uterine Fibroids.  Reproduction (in press).

Lin, Daphne, Carnagarin, Revathy, Dharmarajan, Arun, Dass, Crispin (2017). Transdifferentiation of myoblasts into osteoblasts – possible use for bone therapy. Journal of Pharmacy and Pharmacology (in press).

Bhuvanalakshmi G, Arfuso F, Kumar AP, Dharmarajan A, and Warrier S (2017). Epigenetic reprogramming converts human Wharton’s jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators.  Stem Cell Research and Therapy (In press; DOI 10.1186/s13287-017-0638-7).

Sheena L.P. Regan, Phil G. Knight, John L.Yovich, Yee Leung, Frank Arfuso, Arun Dharmarajan (2017).   Involvement of Bone Morphogenetic Proteins (BMP) in the Regulation of Ovarian Function. Vitamins and Hormones (book chapter).  Elsevier (in press)

Gogoi-Tiwari J, Köhn-Gaone J, Giles C, Schmidt-Arras D, Gratte FD, Elsegood CL, McCaughan GW, Ramm GA, Olynyk JK, Tirnitz-Parker JEE. The murine choline-deficient, ethionine-supplemented (CDE) diet model of chronic liver injury. Journal of Visualized Experiments 2017. In Press.

Pozniak KN, Pearen MA, Pereira TN, Kramer CSM, Kalita-De Croft P, Nawaratna SK, Fernandez-Rojo MA, Gobert, GN, Tirnitz-Parker JEE, Olynyk JK, Shepherd RW, Lewindon PJ, Ramm GA. Taurocholate induces biliary differentiation of liver progenitor cells causing hepatic stellate cell chemotaxis in the Ductular Reaction: Role in pediatric cystic fibrosis liver disease. American Journal of Pathology 2017. In Press.